There are three sticking points in the US-Iran negotiations: control of the Strait of Hormuz, enriched uranium stockpiles, and the unfreezing of Iranian overseas assets.

CoinFeed reported on April 12 that, according to Cailian Press, three main sticking points remain in the US-Iran negotiations: the reopening of the Strait of Hormuz, the issue of enriched uranium, and the unfreezing of Iranian overseas assets. The US has demanded that Iran immediately reopen the Strait of Hormuz, allowing all maritime traffic. Two informed Iranian officials stated that "Iran refuses to relinquish control of this vital waterway" and indicated that it will only do so after a final peace agreement is reached. Iran demands compensation from the US for damage caused by the airstrikes and the unfreezing of frozen oil revenues in Iraq, Luxembourg, Bahrain, Japan, Qatar, Turkey, and Germany for reconstruction purposes. However, the US has rejected these demands. Another remaining issue is that US President Trump has demanded that Iran "hand over or sell its entire stockpile of near-weapon-grade enriched uranium." Officials stated that Iran has submitted a counter-proposal, but the two sides have failed to reach a compromise.